KEGG pathway terms for predicted target mRNAs of miR-558 included AMPK Signaling pathway (P = 4.5E-07), Axon guidance (P = 3.97E-06), Pathways in cancer (P = 8.93E-05), PI3K-Akt signaling pathway (P = 0.0014) and HIF-1 Signaling pathway (P = 0.004). This evidence concerns the gene HIF1A and cancer.