MAPT and Alzheimer disease: It shows significant age-related impairment in memory and learning ability (Akiguchi et al., 2017), and demonstrated many pathological features similar to those of AD patients such as altered amyloid β (Aβ) proteins (Morley et al., 2002), elevated phosphorylation of tau (Canudas et al., 2005), as well as synaptic and dendritic pathological changes (Nomura, 1999).