Furthermore, SAMP8 mice at 6 months of age showed poor performance in ORT test (Adler et al., 2014; Jin et al., 2016), and our treatment of Rb1 and Rg1 effectively enhanced DI in both OLR and NOR tests, which coincide with previous study on Rb1 and Rg1, indicating their positvie effects on promote learning and memory in normal animals or animals with cognitive impairment (Qiong et al., 2014). Here, PPP1R3A is linked to Cognitive impairment.