NLRP3 and brain ischemia: Among those types of inflammasomes, NOD-like receptor pyrin domain containing 3 (NLRP3) possesses a critical role in inflammatory response (Li et al., 2018), and associated with many diseases, including AD, Parkinson's disease, diabetes, atherosclerosis, and cerebral ischemia/reperfusion injuries (Guo et al., 2016; Feng et al., 2018; Li et al., 2019; Nasonov and Popkova, 2018; von Herrmann et al., 2018).