APOC1 and Alzheimer disease: Recently, Kulminski et al. (2019, 2020) and Wolters et al. (2019) documented new AD risk variants in 11 more genes in 19q13.3 (Table 3) Together with its AD-associated genes, the 19q13.3 locus includes more than 50 other genes with diverse functions (Table 3), including lipid metabolism and transport (ApoC1), inflammatory mediators (NFkB, PVRL2), reproductive hormones (luteinizing hormone), and transcription factors (NFkB, zinc finger).