HIF1A and familial pancreatic carcinoma: Additionally, in pancreatic cancer, combination of PX-478, a specific agent suppressing constitutive and hypoxia-induced expression of HIF-1α, with gemcitabine induce immunogenic cell death which is related to repression of HIF-1α via upregulating phosphorylation of eIF2α [99], PX-478 can enhance radiosensitization by inhibition of HIF-1α as well [100].