Moreover, decreased IncRNA-CF129 regulated by HIF-1α/histone deacetylase 1(HDAC1) complex facilitated pancreatic cancer progression via increasing forkhead box C2 (FOXC2) expression, and FOXC2 overexpression was induced by E3 ligase MKRN1-mediated p53 ubiquitin degradation. Here, HIF1A is linked to familial pancreatic carcinoma.