IL-37 expression was decreased in pancreatic cancer, down-regulated IL-37-mediated gemcitabine resistance via interacting with HIF-1α and signal transducer and activator of transcription 3 (STAT3) and forming the HIF-1α/IL-37/STAT3 negative feedback [68]. The gene discussed is HIF1A; the disease is familial pancreatic carcinoma.