We found that EZH2 was the common transcriptional regulator of RP11-89K21.1 and RP11-357H14.17 in endometrial carcinoma with AnnoLnc, Moreover, EZH2 was positively correlated with the expression of RP11-89K21.1 and RP11-357H14.17. This evidence concerns the gene EZH2 and endometrial carcinoma.