MMP9 and neoplasm: However, another study by Tai et al. found that macrophage-specific CD68 promoter-driven DCR3 overexpression in transgenic mice strongly induces tumour-associated macrophages and IL-1ra and IL-10 expression; reduces proinflammatory cytokines (TNFα and IL-6); and does not affect MMP2, MMP9, or bone development in mice [27].