When patients were stratified by HIV infection, HCV-monoinfected patients had association with CTP score for IL-8 (q-value= 0.001), IL-6 (q-value= 0.002), OPG (q-value= 0.001), sVCAM-1 (q-value <0.001), sICAM-1 (q-value <0.001), and sTNF-R1 (q-value= 0.002); while HIV/HCV-coinfected patients only showed significant association with CTP score for IL-6 (q-value= 0.007) and sICAM-1 (q-value= 0.007). This evidence concerns the gene CXCL8 and HIV infectious disease.