Increased plasma IL-6 and IP-10 levels are related to liver disease severity in HCV-infected patients11,38 and HIV/HCV-coinfected patients24, but in the current study, we found plasma IL-6 and IP-10 levels discriminated with great accuracy the presence of severe cirrhosis with Child-Pugh B (CTP 7–9). Here, CXCL10 is linked to liver disorder.