In our study, we found a significant association between plasma biomarkers linked to inflammation [inflammatory response (IP-10, IL-8, IL-6, and OPG) and endothelial dysfunction (sVCAM-1 and sICAM-1)] and CTP score in all patients with advanced HCV-related cirrhosis so that the highest levels of these biomarkers were found in patients with greater severity of cirrhosis, suggesting a more pronounced inflammatory CAID phenotype, which is in line with previously published data in patients with severe cirrhosis5,6. This evidence concerns the gene IL6 and endothelial dysfunction.