As shown in Fig. 2B, median NfL levels were similar between the 17 patients that were determined at baseline to have PPMS (n = 17, NfL = 9.68 ± 6.72 pg/mL), RRMS (n = 35, NfL = 10.44 ± 7.26 pg/mL) and CIS (n = 15, NfL 12.0 ± 9.8 pg/mL). The gene discussed is NEFL; the disease is in situ carcinoma.