For conversion to progressive MS in long-term follow-up, baseline serum NfL value of 7.62 pg/mL demonstrated 93.3% (95% CI 68.0–99.8) sensitivity, 46.1% (30.1–62.8) specificity with an NLR of 0.14 (95% CI 0.02–0.99), PLR of 1.73 (95% CI 1.26–2.39) and accuracy of 63.1%. This evidence concerns the gene NEFL and myeloid sarcoma.