Uchida et al. demonstrated the therapeutic effect of ripasudil in an endotoxin-induced rat uveitis model12, in which ripasudil inhibited LPS-induced nuclear translocation of Nuclear factor-kappa beta (NF-κB), adhesion molecules, and proinflammatory mediators, including monocyte chemotactic protein-1 (MCP-1), a key chemokine in chronically inflamed eyes25. This evidence concerns the gene NFKB1 and uveitis.