RRM2 and liver cancer: Importantly, bathing cells in exogenous dNTP pools dose-dependently rescues the proliferation phenotype caused by lincNMR knockdown in two liver cancer cell lines, which is in good accordance with previous studies stating that increasing dNTP levels by RRM2 overexpression or exogenous nucleoside supply overcomes aberrant DNA replication, DNA damage, and senescence induced by oncogenic RAS or BRAF51,52.