Extracellular flux analyses have so far been reported only recently in FRDA cellular models, namely in sensory neurons differentiated from induced pluripotent stem cells derived from patients harboring homozygous repeat expansions (i.e. chronically low FXNWT expression) (Igoillo-Esteve et al., 2020) and an inducible FXN overexpression HEK293 cell line (i.e. short-term high FXNWT expression) (Vannocci et al., 2018). Here, FXN is linked to Friedreich ataxia.