In order to further investigate the potential vascular damage in ALS-CP, we focused on CD31, also known as platelet endothelial cell adhesion molecule-1 (PECAM-1), an endothelial cell marker that localizes to intercellular junctions, and plays an important role in endothelial cell adhesion, but also implicated in T-cell homeostasis and trafficking [46, 48, 56]. The gene discussed is PECAM1; the disease is amyotrophic lateral sclerosis.