Another case is that the autosomal dominant polycystic kidney disease in humans often inherits heterozygous loss-of-function mutations in either PKD1 (polycystic kidney disease-1) or PKD2 (polycystic kidney disease-2), while the mice displays only very mild cystic disease in the same situation [101, 102]. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.