Therefore, the lipids (Low Density Lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride) and inflammation factors (cysteine protease inhibitor C and high-sensitivity C-reactive protein (hs-CRP)) combined with biomarkers of cardiac disease (brain natriuretic peptide (BNP), creatine kinase-MB (CK-MB) and cardiac troponin I (cTnl) etc.)are widely used in clinic diagnosis of ACS and evaluation of ACS risk. This evidence concerns the gene NPPB and heart disorder.