Because non-neurologic disease controls had significantly more hippocampal dentate gyrus cells than FTLD-TDP, ALS, or AD subjects, we repeated this comparison after normalizing RBM45 inclusions to the number of cells and found that FTLD-TDP had significantly more nuclear inclusions per cell than ALS, AD, and control subjects (p < 1 × 10− 6, p < 1 × 10− 8, respectively). This evidence concerns the gene RBM45 and nervous system disorder.