RBM45 is a developmentally regulated RNA binding protein (RBP) that forms nuclear and cytoplasmic inclusions in neurons and glia in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP), and Alzheimer’s disease (AD) [1, 2]. This evidence concerns the gene RBM45 and Alzheimer disease.