The transcriptional master regulator, POU2F3, which defines the tuft cell-like SCLC lineage [2, 12, 13], is epigenetically silenced in cervical cancer via hypermethylation of the POU2F3 promoter [14], suggesting the possibility that DNA methylation-mediated regulatory mechanisms could play a role in SCLC development and progression. This evidence concerns the gene POU2F3 and small cell lung carcinoma.