While many associations of SCLC methylation patterns with drug response were not specific to particular SCLC lineages in our dataset, several lineage-specific associations, e.g., that of YAP1 methylation and expression with rapamycin confirming the results from an earlier study [65], and methylation and expression of DLL3, which is upregulated in ASCL1-high tumors, with Bcl-2 inhibitors were identified. Here, DLL3 is linked to small cell lung carcinoma.