Consistent with association with vinorelbine, TREX1 promoter methylation and expression were correlated with other antimitotic agents including vinblastine, vincristine, and paclitaxel in SCLC lines from both GDSC1 and GDSC2 datasets (for multiple promoter methylation measures, − 0.7236 ≤ ρ ≤ − 0.4196, 0.0001 ≤ pO ≤ 0.0262; for expression, 0.3553 ≤ r ≤ 0.5186, 0.0061 ≤ pO ≤ 0.0362; data not shown). Here, TREX1 is linked to small cell lung carcinoma.