MYCN and small cell lung carcinoma: Interestingly, whereas c-Myc directly upregulates expression of Aurora kinase genes and promotes a neuroendocrine-low subtype of SCLC which is sensitive to Aurora kinase inhibitors [10, 57], the expression of TREX1 was not associated with transcriptional levels of either MYC, MYCL, or MYCN (|r| < 0.13), even though methylation of the 5′UTR and the first exon of TREX1 was weakly associated with MYC expression (r = 0.328 and 0.326, pO = 0.0076 and 0.0072, respectively; data not shown).