Associations of TREX1 promoter methylation and expression with log(IC50) of vinorelbine were validated in SCLC cell lines from the CCLE and GDSC datasets (− 0.6506 ≤ Spearman ρ ≤ − 0.4275, 0.0006 ≤ pO ≤ 0.0207 for significant correlations of various measures of TREX1 promoter methylation and log(IC50) of vinorelbine from both GDSC1 and GDSC2; Pearson r = 0.6245, pO = 0.0006 for correlation between TREX1 expression and vinorelbine response from GDSC2; data not shown). Here, TREX1 is linked to small cell lung carcinoma.