We observed correlations between EZH2 expression and expression of YAP1 (transcript cluster ID 3346453; r = − 0.397, pO = 0.0010), MYCN (2470838; r = 0.328, pO = 0.0071) and, most strongly, MYC (3115504; r = − 0.512, pO = 1.098 × 10−5), which suggest a potential mechanism linking expression of SCLC master lineage regulators and epigenetic pathways of lineage differentiation; however, these correlations do not provide evidence that this mechanism could involve the methylation of the EZH2 promoter region. Here, EZH2 is linked to small cell lung carcinoma.