Other potential biomarkers, like density, phenotype, and diversity of tumor-infiltrating lymphocytes (TILs), tumor mutational burden, rare JAK2 or B2M mutations, and specific gut microbial species can also correlate with response to anti-PD-1 therapy, but remain imperfect predictors of a response to PD-1 blockade [12]. The gene discussed is JAK2; the disease is neoplasm.