We obtained similar results with a pre-ranked list of LARGE2 correlated genes derived from the CRIS gene expression data set (n = 515 PDX CRC samples) [30] (Fig. 2H and Additional file 4H-J) and from microarray data (n = 58 established CRC cell lines) obtained from the Cancer Cell Line Encyclopedia (CCLE) [52] (Fig. 2I and Additional file 4 K,L). This evidence concerns the gene LARGE2 and cancer.