Together with our data on the liver-metastatic KM12c cell derivative KM12-L4a [62], which show that Wnt/LARGE2/α-DG signaling augments CRC cell adhesion to blood vessel endothelial cells, we speculate that CRC cell (sub)-populations highly positive for O-glycosylated α-DG might get either selected for or simply become enriched due to their enhanced blood-vessel adhesiveness during liver colonization. Here, LARGE2 is linked to colorectal carcinoma.