LARGE2 and colorectal carcinoma: In silico analysis of putative TCF7L2 genomic DNA binding loci in HCT116 CRC cells via the UCSC genome browser revealed DNA occupation by TCF7L2 within the first intron of LARGE2 (ENCODE annotation data [41], Farnham-USC, Accession No: ENCSR000EUV) (Fig. 1G).