From our in vitro functional data on Wnt/LARGE2/α-DG signaling, we can only speculate that the here identified Wnt/LARGE2/α-DG signaling pathway might play a dual role in CRC progression by limiting early tumor cell migration/dissemination while presumably facilitating liver colonization of intravasated, circulating CRC cells. Here, LARGE2 is linked to colorectal carcinoma.