The stronger than “just-right” Wnt dose in pre-malignant ADO-ex7 organoids provoked elevated LARGE2 gene expression and the formation of “above-normal” molecular weight matriglycan structures on α-DG (> 140 kDa), suggesting that LARGE2/α-DG-mediated laminin adhesion might be oncogenic Wnt dose-dependent at this earliest, pre-malignant stage of CRC. The gene discussed is LAMB2; the disease is colorectal carcinoma.