Wnt signaling plays a pivotal role in human colonic stem cell (hCoSC) and colorectal cancer (CRC) biology [1, 2], and constitutive Wnt activation in CRC frequently arises from mutations in the tumor suppressor gene APC. Wnt activity in APC mutant CRC cells at least partially depends on the length of truncated APC [3]. The gene discussed is APC; the disease is colorectal cancer.