LARGE2 and colorectal carcinoma: Albeit our in vitro data point to a rather anti-cell migratory effect of Wnt/LARGE2/α-DG signaling, adhesion of CRC cells to ECM components of the liver sinusoid plays an important role in the formation of liver metastasis: E.g. therapeutic interference with integrin α2-collagen IV or BCAM-laminin interactions prevented the liver metastatic spread of CRC cells in mouse models [64, 79].