LARGE2 and colorectal carcinoma: Since Wnt signaling represents a major driver of stemness in colonic epithelium and CRC [51], we studied the enrichment of two published gene sets specifying EPHB2high and PTK7high hCoSCs [2, 34] in the LARGE2 signature of CRC: Both hCoSC-specific gene sets were enriched among the genes positively correlated with LARGE2 expression (Fig. 2F,G and Additional file 4F,G).