There was also evidence indicating the transcription of SMC4 was activated by NF-κB through regulation of miR-16 and miR-21 in gastric cancer, and SMC4 could participate in chronic lymphocytic leukemia (CLL) with post-transcriptional regulation of miR-15/− 16 family members [42]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.