TNF and rheumatoid arthritis: For example, in the field of autoimmune disease, mAbs such as Infliximab (Remicade®; Janssen Biotech) or Adalimumab (Humira®; Abbott), work directly against the pro-inflammatory cytokine, tumor necrosis factor α (TNF-α) to treat severe rheumatoid arthritis (RA) [44, 115, 172, 175].