Since the ob gene was cloned in 1994 and subsequently its product leptin, primarily expressed in adipocytes, was found to have functions in regulating satiety and energy metabolism [2–4], several other adipokines including adiponectin and resistin have been found and highlighted in obesity pathogenesis and its associated complications [5, 6]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.