DHRS2 is suggested to be a tumor suppressor gene in different tumor types, including nasopharyngeal carcinoma [31,32], gastrointestinal stromal tumors [33,34], metastatic lung adenocarcinomas [35], esophageal squamous cell carcinoma [30], and renal cancer [36]. This evidence concerns the gene DHRS2 and esophageal squamous cell carcinoma.