LEF1 and cancer: After GO enrichment analysis, we searched for the associated pathways for the DEGs using the KEGG and found that metabolic pathways, pathways in cancer, viral carcinogenesis, transcriptional dysregulation in cancer, mitogen-activated protein kinase signaling, and the PI3K-Akt pathway were among the aberrantly expressed signaling pathways in LEF1-downregulated cells (Table 2).