Additionally, isolation of CD34+ cell populations from PLC/PRF/5 hepatocellular carcinoma (HCC) can form three different histological types of liver cancer in immunodeficient mice, including hepatocellular carcinoma and hepatocellular cholangiocarcinoma (CCA), implying that CD34+ HCC cells could be a potential subtype of liver cancer stem cells (CSCs) [50]. The gene discussed is CD34; the disease is liver cancer.