SOD1 and amyotrophic lateral sclerosis: Although the latest research suggests that p38 and JNK MAPK play a determinant role in ALS [175], ERK pathway alteration is also related, since SOD1(G93A) transgenic mice present a dysregulation in axonal transport associated with the down-regulation of ERK correlating with the up-regulation of JNK and caspase-8 [147].