TRPV1 and myocardial ischemia: Moreover, decreased myocardial TRPV1 expression was accompanied by reduced CGRP and SP release into coronary effluent after myocardial ischemia in the isolated hearts of type I diabetic rats as compared to non-diabetic ones, leading to the loss of ischemic postconditioning-induced cardioprotection and impaired myocardial function [97].