TRPV1 and hypertensive disorder: An early study using Dahl salt-sensitive and salt-resistant rats subjected to low- and high-salt diets for 3 weeks was the first to show that TRPV1 protein expressions in mesenteric arteries and kidney samples are upregulated due to increased salt intake and the overexpression of TRPV1 prevents the development of salt-induced hypertension only in salt-resistant animals [110].