In a rat model with HF induced by 4-week coronary ligation, intrathecal RTX pre-treatment significantly reduced dorsal horn TRPV1 expression and reduced cardiac sympathetic nerve overactivation, which reversed epicardial monophasic APD prolongation and decreased action potential alternans and ventricular arrhythmia development evoked by programmed electrical stimulation [128]. The gene discussed is TRPV1; the disease is hydrops fetalis.