It was approved in 2001 by FDA as first-line therapy for CML patients by obtaining optimal results compared to those who had been treated with hydroxyurea and IFN-α in terms of CHR (Complete Hematological Response), CCR (Complete Cytogenetic Response), and MMR (Major Molecular Response). The gene discussed is IFNA17; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.