Since IFN-γ is pivotal for the immune response to Salmonella bacteria [33], it would be interesting to investigate if a reduced IFN-γ response in the face of FAT10 deficiency, as found for splenocytes from LCMV-WE-infected mice, contributed to the enhanced susceptibility of FAT10-/- mice to infection with S. typhimurium. The gene discussed is IFNG; the disease is infection.