ROR1 and diffuse large B-cell lymphoma: To further address the significance of ROR1 in DLBCL, we performed functional studies on DLBCL cell lines, using a second generation small molecule ROR1 inhibitor, KAN0441571C, which was superior to our first generation [KAN0439834 [29]] in inducing apoptosis of DLBCL cells and with improved pharmacokinetics.