CASP9 and diffuse large B-cell lymphoma: We also showed that KAN0441571C inhibited ROR1 phosphorylation in DLBCL cells and induced apoptosis is mainly through the intrinsic mitochondrial pathway, inhibiting pro-survival molecules (BCL-2 and MCL-1) and the upregulation of the pro-apoptotic BAX protein as well as cleavage of caspase 9 at low concentrations of the ROR1 inhibitor.