IRF4 and diffuse large B-cell lymphoma: Notably, sets of genes upregulated after IRF4 and/or SPIB knockdown in activated B-cell (ABC)-type diffuse large B-cell lymphoma (DLBCL) cell line [15] (IRF4_ABC_REPRESSED_ALL and IRF4_SPIB_ABC_REPRESSED_ALL; NES = 1.38 and 1.55; FDR q-value = 0.17 and 0.07) were also significantly enriched in NMZLs.