VEGFA and renal cell carcinoma: Grange et al. reported that treatment with the intravenous injection of EVs derived from CD105-positive renal cell carcinoma modified the lung microenvironment by enhancing the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase 2 (MMP2) in lung endothelial cells and that of MMP9 in whole lung tissue [56].