NLRP3 and cryopyrin-associated periodic syndrome: For example, in patients with CAPS, positional cloning revealed that heterozygous mutations in NLRP3 could be the cause of most cases with GOF mutations in NLRP3 gene located in chromosome 1q44 and associated with the constitutive activation of the NLRP3, leading to spontaneous activation of caspase-1 and an excess of IL-1β production [60].