NLRP3 and atherosclerosis: In light of the above-reported relevance of the activation of the NLRP3 inflammasome-IL-1β pathway for ASCVD progression and, in some cases, the apparently protective effects of some related SNPs, the assessment of a panel of NLRP3-associated SNPs may be reasonably implemented in the context of novel CVD risk algorithms which include genetic biomarkers.