Cell lines HCT116, H-29, SW480, Colo-320 [69]Orthotopic C57BL/6 mice using MC38 colorectal cancer cells [69]Azoxymethane induced polyps in C57BL/6 immune-competent mice [44]Decreased Klotho expression in colon cancer tissues [45]. The gene discussed is KL; the disease is colorectal cancer.