Only a missense [(NM_001142966.2:c.848A>G:p.(Asn283Ser)] variant in GREB1L, a gene previously associated with HI, segregated with HI in pedigree 4697 with an AD mode of inheritance (Table 1, Figure 1, Figure S1) [6]. The gene discussed is GREB1L; the disease is Alzheimer disease.