Although LCSCs and cells undergoing EMT contribute to the cellular heterogeneity within the tumor, these transformed cells share common genetic signatures, such as high expression of cell adhesion surface glycoproteins (CD44, CD133, CD13, CD24, CD90, EpCAM, and N-cadherin), aldehyde dehydrogenase 1A1 (ALDH1A1), keratin-19 (KRT19), and transcription factors (SNAI1, SLUG, TWIST1, ZEB1, and ZEB2) [161,162,163]. Here, ALDH1A1 is linked to neoplasm.