Similarly, radiosensitivity and apoptosis were induced by miR-22-mediated inhibition of SIRT1 in breast cancer cells, by miR-34a-mediated inhibition of LyGDI in non-small cell lung cancer (NSCLC) cells and by miR-124-mediated inhibition of CDK4 in ESCC and glioma cells [21,28,35,36]. This evidence concerns the gene CDK4 and non-small cell lung carcinoma.