The high expression and essentiality of YBX1 in the tested cell lines as well as its high expression levels in medulloblastoma patients supports the hypothesis, that YBX1 also plays an important role in cell survival in medulloblastomas and likely also in this cancer acts as an oncogene as was reported for other cancers [43,44,45]. This evidence concerns the gene YBX1 and medulloblastoma.