We performed a population-based case-control study to investigate the possible modifying effect of four polymorphisms in VEGFA, one in VEGFR1 and another in bFGF. Subsequently, we also examined the relationship between VEGFA, VEGFR1 and bFGF polymorphisms variants and prognostic factors, the clinical parameters of the disease and the relationship with survival in B-CLL patients. The gene discussed is FLT1; the disease is B-cell chronic lymphocytic leukemia.