The rs1547651 VEGFA polymorphism showed association with several factors including Rai and Binet stages (p-value = 0.0058; OR = 0.38 (95% CI: 0.18–0.79) and p-value = 0.0059 OR = 0.13 (95% CI: 0.02–0.97), respectively), the presence of lymphadenopathies (p-value = 0.021; OR = 0.44 (95% CI: 0.21–0.92)) and hemoglobin levels (p-value < 0.0004; OR = 4.90 (95% CI: 2.24–7.57)) at diagnosis. This evidence concerns the gene VEGFA and Lymphadenopathy.