As shown Figure 4, the proteins C4a (panel a) and APOA4 (panel b) were found in lower concentrations in DBA/2J_G10 and DBA/2J_G14 groups when compared to DBA/2J_G4 group, depicting a age- and/or disease-related decrease in the DBA/2J mice developing glaucoma. Here, APOA4 is linked to glaucoma.