The proteins ITIH4 and CFH (panels c and d of Figure 4) were found in higher concentrations in 10 and 14 month old glaucomatous mice (DBA/2J_G10 and DBA/2J_G14) compared to preglaucomatous stage (DBA/2J_G4), therefore suggesting changes in the transition phase to glaucoma. The gene discussed is ITIH4; the disease is glaucoma.