INS and Impaired glucose tolerance: Within 8 weeks of feeding, 145E mice showed increases in food intake (Figure 2A), body weight (Figure 2B), feeding efficiency (Figure 2C), liver mass (Figure 2D), epididymal fat mass (Figure 2E), fasting glucose (Figure 2F), and insulin (Figure 2G), as well as impaired glucose tolerance (Figure 2H,I).