Hu et al. [167] further suggested the modulatory role of the CXCL16/CXCR6 axis in metastasis of prostate cancer to skeletal tissues, as is typically observed with CXCL12, and showed how CXCL16 secreted by bone cells can attract prostate tumors into bone structures. This evidence concerns the gene CXCL12 and Familial prostate cancer.