Despite the low levels of endogenous CXCR4 expression in LNCaP and DU-145 cells, it was found that CXCL12 facilitated increased adhesion of these prostate cancer cells to monolayers of endothelial cells and immobilized matrix through enhanced expression of α5 and β3 integrins [143]. The gene discussed is CXCL12; the disease is prostate carcinoma.