TNFRSF11A and metastatic malignant neoplasm: The suggestion of a correlation existing between the RANKL/RANK/OPG axis and metastatic prostate carcinoma was reported by Chen et al. [149], who described high expression of RANKL and its receptor (RANK) in metastatic cancer, with attendant higher prevalence of these proteins in bone metastasis as compared to lymph node.