Among the most important cytokines/chemokines associated with prostate cancer metastasis and discussed herein includes IL-6, CXCL12, TGFβ, CXCL8, VEGF, RANKL, CCL2, CX3CL1, IL-1, IL-7, CXCL1 and CXCL16. This evidence concerns the gene CXCL12 and Familial prostate cancer.