TGFB1 and Familial prostate cancer: During the early phase of metastasis, cytokines such as TGFβ, IL-6, CXCL8, IL-7, CXCL16, and CX3CL1 induce EMT in prostate cancer cells and transforms them to exhibit higher migratory and invasive potentials [76,77,80,81,122].