CXCL12 and Familial prostate cancer: In evaluating the role of the CXCL12/CXCR7 axis in prostate cancer metastasis, Wang et al. [209], for example, described how overexpression of CXCR7 in human prostate cancer cell lines enhanced in vivo tumor growth and promoted metastasis via increased release of angiogenic cytokines, such as CXCL8 and VEGF.