DeRycke et al. [71] performed exome sequencing in 16 families affected with CRC, identifying several predicted pathogenic variants in genes coding for mitotic factors, such as CDC27, DDX12, HAUS6/FAM29A, HIST1H2BE, TACC2, and ZC3HC1, and paying special attention to KIF23 and CENPE, located within previously reported CRC linkage regions [73]. The gene discussed is TACC2; the disease is colorectal carcinoma.