In total, 7 out of the 16 identified candidates belonged to DNA repair pathways, and 4 of them were involved in DSB repair: BRCA2, RIF1, BLM, and RECQL. BRCA2 is a classical non-CRC cancer predisposition gene that predisposes to hereditary breast and ovarian cancer and its implication in HNPCC will be discussed in Section 4. Here, BRCA2 is linked to hereditary nonpolyposis colon cancer.