In total, 7 out of the 16 identified candidates belonged to DNA repair pathways, and 4 of them were involved in DSB repair: BRCA2, RIF1, BLM, and RECQL. BRCA2 is a classical non-CRC cancer predisposition gene that predisposes to hereditary breast and ovarian cancer and its implication in HNPCC will be discussed in Section 4. The gene discussed is BRCA2; the disease is ovarian cancer.