This unusual DS-1-like G3P[8] strain has been identified in several countries with a range of vaccine coverage, with different rates of infection depending on geographic and temporal patterns, including Australia, Germany, Hungary, USA, Brazil, Japan, and Thailand [10–12, 20, 36, 38, 42–46], indicating that the DS-1-like backbone is derived from a globally circulating pool of RV. Here, MRPL58 is linked to infection.