In summary, the peritumor/tumor apparent diffusion coefficient ratio correlated significantly with histopathological biomarkers such as tumor size, tumor grade, Ki-67 index, presence of lymph-node metastasis, and lymphovascular invasion, as well as with published prognostic indexes, Nottingham Prognostic Index and PREDICT, in patients with invasive breast cancer. Here, MKI67 is linked to metastatic malignant neoplasm in the lymph nodes.