In summary, the peritumor/tumor apparent diffusion coefficient ratio correlated significantly with histopathological biomarkers such as tumor size, tumor grade, Ki-67 index, presence of lymph-node metastasis, and lymphovascular invasion, as well as with published prognostic indexes, Nottingham Prognostic Index and PREDICT, in patients with invasive breast cancer. The gene discussed is MKI67; the disease is neoplasm.