For this purpose, the expression of the tumor suppressor gene p16INK4a was investigated and its overexpression was observed in 30.5% (n = 28) of CRC cases, with only three of these cases being positive for HPV detection, suggesting that in fact the virus was not involved in the carcinogenic process of these tumors, and that its presence is considered incidental. Here, CDKN2A is linked to colorectal carcinoma.