CDKN2A and metastatic malignant neoplasm in the lymph nodes: A recent meta-analysis investigated the prognostic relevance of p16INK4a in CRC and suggested that its overexpression could be correlated with the Dukes stage, the presence of lymph node metastasis, and the TNM stage (only in Caucasians), implying in a relevant role for p16INK4a protein in the development of CRC [102].