The pathways induced by these stimuli finally converge in a set of senescence genes, the best known of which are the tumor suppressors Cdkn2a-p16, Cdkn2a-p19, Cdkn1b-p27, Cdkn2b-p15 or Cdkn1a-p21, resulting in proliferative arrest [9, 10]. The gene discussed is CDKN2B; the disease is neoplasm.