Considering that hsa-miR-660-3p inhibitor and TEP1 overexpression reappear well the phenotypes of hsa_circ_0004018 downregulation (Figures 4, 6), we highlight the hsa_circ_0004018/hsa-miR-660-3p/TEP1 axis in the proliferation and activation of HSCs and liver fibrosis. The gene discussed is TEP1; the disease is Hepatic fibrosis.