GSK3B and Anxiety: Stimulation of D2 receptor results in an increase of GSK3β activity.44 Interestingly, elevated D2 receptor availability in the PFC was found in patients with anxiety disorder compared to healthy subjects.45 Moreover, a decrease in anxiety symptoms after therapy was significantly correlated with the decrease of D2 receptor availability in the PFC.46 These findings strongly support a role of GSK3β in the regulation of anxiety-related behaviors downstream of D2 receptors in the mPFC of the adult brain.