Accumulating evidence was illustrating that FAM83H‐AS1 was overexpressed in various cancer types that promoted cell growth and metastasis by multiple molecular mechanisms,13, 14, 15, 16 while the exact mechanism of FAM83H‐AS1 in ESCC was largely unclear and its prospect as therapeutic target for ESCC was still unexplored. Here, SACK1H is linked to esophageal squamous cell carcinoma.