In this study, the mRNA expression levels of METTL3, MTEEL14, WTAP, FTO, ALKBH5, and YTHDF2 in PBMCs from SLE patients and HC were detected, and we found that the mRNA expression levels of MTEEL14, ALKBH5, and YTHDF2 in PBMCs from SLE patients were significantly decreased than HC, suggesting that the down expression of MTEEL14, ALKBH5, and YTHDF2 in PBMCs in SLE may affect the m6A modification of some genes in SLE, and then promote the development of SLE. This evidence concerns the gene WTAP and systemic lupus erythematosus.