And, our results showed a direct relationship between these serum biomarkers and alterations in mRNA expression (METTL14, ALKBH5, and YTHDF2), suggesting easily obtainable and highly informative laboratory parameters can be used to monitor the course of SLE patients and METTL14, ALKBH5, and YTHDF2 may be used as routine clinical parameters. Here, YTHDF2 is linked to systemic lupus erythematosus.