In this study, we investigated the correlations between the expression of METTL14, ALKBH5, and YTHDF2 and clinical data in SLE patients, and results showed that the down expression of METTL14 was associated with WBC, M, CRP, and fever, the down expression of ALKBH5 was associated with N%, L%, NLR, C3, and fever, and the down expression of YTHDF2 was inversely associated with L%, NLR, C3, and fever, suggesting downexpression of METTL14, ALKBH5, and YTHDF2 was associated with disease activity in SLE. This evidence concerns the gene YTHDF2 and systemic lupus erythematosus.