As shown in Figure 4, the expression of ALKBH5 and YTHDF2 in PBMCs from SLE patients with fever was significantly decreased than that in SLE patients without fever (all p < .050), while the expression of METTL14 in PBMCs from SLE patients with fever trends to reduce, but a significant difference was not reached (p = .067). The gene discussed is ALKBH5; the disease is systemic lupus erythematosus.