As shown in Table 3, we acquired the equation about the expression of METTL14, ALKBH5, and YTHDF2 in PBMCs, Y = −1.112 X1(METTL14) + 201.063 X2(ALKBH5) − 81.543 X3(YTHDF2) + 5.242, and only the decreased expression of YTHDF2 in PBMCs was a risk factor for SLE (p < .001). This evidence concerns the gene METTL14 and systemic lupus erythematosus.