The present study aimed to determine the mRNA expression level of METTL3, MTEEL14, WTAP, FTO, ALKBH5, and YTHDF2 in PBMCs from SLE patients using quantitative real‐time polymerase chain reaction (qRT‐PCR), which investigating whether m6A play a role in the occurrence and development of SLE. This evidence concerns the gene YTHDF2 and systemic lupus erythematosus.