To investigative the expression of METTL3, METTL14, WTAP, ALKBH5, FTO, and YTHDF2 in patients with SLE and HC, PBMCs from 28 SLE patients and 26 age‐ and sex‐matched HC were collected to detect their expression using qRT‐PCR. This evidence concerns the gene METTL3 and systemic lupus erythematosus.