UPP1 and familial pancreatic carcinoma: Uridine phosphorylase 1 (UPP1) has been reported as an oncogene across a range of malignant tumors, including colorectal cancer (CRC),4 esophageal squamous cell carcinoma (ESCC),5 thyroid carcinoma,6 pancreatic cancer,7 oral squamous cell carcinoma,8 and breast cancer.9