Uridine phosphorylase 1 (UPP1) has been reported as an oncogene across a range of malignant tumors, including colorectal cancer (CRC),4 esophageal squamous cell carcinoma (ESCC),5 thyroid carcinoma,6 pancreatic cancer,7 oral squamous cell carcinoma,8 and breast cancer.9 This evidence concerns the gene UPP1 and colorectal cancer.